Post by Annette
Then again, I no longer
take any oral meds.
I have some good reasons, but that's another story.
On another occasion you mentioned that you take alpha lipoic acid (ALA).
Since it is a prescription med in Germany, I sort of consider it a
medicine that gets by as an over the counter supplement. While it it is
an antioxidant that helps to recycle both water and oil based vitamins,
it also acts as an insulin mimic in a dose dependent fashion (high
enough level). ALA is also time dependent. I don't use a delayed release
version but take it four times a day (after meals [1,2,2] and at bedtime
). Susan Fein doen't see the non-time release version helpful but it
is effective for me.
Both alpha lipoic acid and n-acetyl-L-cysteine are thiols. This article
is a good summary of thiols. The right side spanner offers a basic
outline of this article.
"Thiol redox cycles play central roles in the antioxidant defense
network. Both glutathione and lipoate redox cycles can be driven by
cellular-reducing equivalents to generate their respective reduced forms
(GSH and DHLA). The ability of lipoate to increase cell GSH is mediated
by the reduction of cystine to the GSH precursor cysteine by
dihydrolipoate. LA, lipoate; GSSG, oxidized glutathione; vit, vitamin.
For more details on antioxidant interaction ..." Source: Figure 1 Thiol
redox cycles - Thiol homeostasis and supplements in physical exercise
In addition to regular vitamin C (which has a short life) which I take
at mealtimes, I recently started using ascorbyl palminate - a longer
lasting vitamin C - at bedtime. My fasting bg have gone down quite a
Since I haven't done this for very long, the jury is still out.
Ascorbyl palmitate is a little-known fat-soluble form of Ascorbic Acid,
or Vitamin C. Unlike Ascorbic Acid, which is water-soluble, it is able
to be stored in cell membranes until needed by the body. As a form of
Vitamin C, Ascorbyl Palmitate is an effective free radical-scavenging
The following are a shotgun of connections:
The Glucose/Insulin System and Vitamin C: Implications in
Insulin-Dependent Diabetes Mellitus
Increased Accumulation of the Glycoxidation Product
N-(carboxymethyl)lysine in Human Tissues in Diabetes
and Aging (There are lengthy citations using this article.)
Obesity and Body Fat Distribution Induce Endothelial
Dysfunction by Oxidative Stress - Protective Effect of Vitamin C
Aging: Is Oxidative Stress a Marker or Is It Causal?
"Diabetes provides a distinct model of chronic vascular disease in which
disordered glucose homeostasis triggers abnormalities eventuating in
dysfunction of virtually every organ, deriving, in part, from vascular
perturbation. Although superimposition of other risk factors, such as
hyperlipemia or hypertension, adds to the complex atherogenic milieu,
diabetes by itself is a
well-recognized independent cardiovascular risk factor.8 9 10 11 12 In
fact, up to 80% of deaths in patients with diabetes are closely
associated with vascular disease. The impact of diabetic complications
in economic terms is emphasized by the consumption by diabetic patients
of the largest share of the health care dollar in the United States
compared with any other single disease." Source: Activation of Receptor
for Advanced Glycation End Products - A Mechanism for Chronic Vascular
Dysfunction in Diabetic
Vasculopathy and Atherosclerosis
Google group threads:
In the year 2000, Quentin had a query on this topic. Does ascorbyl
palmitate also require insulin
to enter cells? It doesn't appear that he received an answer to his
An article that cites ascorbyl palmitate:
Oxidation of Free Fatty Acids in Low Density Lipoprotein by
15-Lipoxygenase Stimulates Nonenzymic,
alpha-Tocopherol-mediated Peroxidation of Cholesteryl Esters